Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence.
The basic concept of conditionally replicating adenoviruses (CRAD) as oncolytic agents is that progenies generated from each round of infection will disperse, infect and kill new cancer cells.However, CRAD has only inhibited, but not eradicated tumor growth in xenograft jackets tumor therapy, and CRAD therapy has had only marginal clinical benefit