FIBER MEDIATED RECEPTOR MASKING IN NON-INFECTED BYSTANDER CELLS RESTRICTS ADENOVIRUS CELL KILLING EFFECT BUT PROMOTES ADENOVIRUS HOST CO-EXISTENCE.

Fiber mediated receptor masking in non-infected bystander cells restricts adenovirus cell killing effect but promotes adenovirus host co-existence.

The basic concept of conditionally replicating adenoviruses (CRAD) as oncolytic agents is that progenies generated from each round of infection will disperse, infect and kill new cancer cells.However, CRAD has only inhibited, but not eradicated tumor growth in xenograft jackets tumor therapy, and CRAD therapy has had only marginal clinical benefit

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ELOTUZUMAB FOR THE TREATMENT OF RELAPSED OR REFRACTORY MULTIPLE MYELOMA, WITH SPECIAL REFERENCE TO ITS MODES OF ACTION AND SLAMF7 SIGNALING

Elotuzumab, targeting signaling lymphocytic activation molecule family 7 (SLAMF7), has been approved in combination with lenalidomide and dexamethasone (ELd) for relapsed/refractory multiple myeloma (MM) based on the findings of the phase III randomized trial ELOQUENT-2 (NCT01239797).Four-year follow-up analyses of ELOQUENT-2 have demonstrated that

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Aneurysmal Subarachnoid Hemorrhage: Is the Time Until Intervention Related to Minor Disabilities in 6 Months?

Background Aneurysmal subarachnoid hemorrhages (aSAHs) account for 5% of all strokes, an appalling number when it comes to the second most common cause of death jackets worldwide.The basis of the treatment is clinical support and either endovascular or surgical intervention.The purpose of the Idler Assembly present study is to analyze if the time f

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